Panov V.P., Logunov D.L., Avdeeva M.V.
North-Western State Medical University named after I.I. Mechnikov, St. Petersburg

Contacts: Marina Avdeeva, This e-mail address is being protected from spam bots, you need JavaScript enabled to view it

Abstract. Significance. To some extent human health depends upon degree of compliance with medical advice making it significant to study and analyze causes of insufficient adherence to medical and preventive interventions and healthy lifestyle.

The purpose of the study: to analyze data on current scientific research focused on causes of non-compliance with medical advice and substantiate measures aimed at improving public health through better adherence to medical and preventive interventions.

Methods: Content analysis, analytical, historical.

Results. Numerous studies have demonstrated that the main reasons of non-compliance with treatment and unhealthy lifestyle include the following: 1) social/economic factors, 2) state of the health care system, 3) patient’s health status, 4) therapy-related factors and 5) human behavioral characteristics. At the same time, because of improper attitude towards health a certain part of the population is unable to make the most of medical care resulting in lower efficiency of treatment, deteriorated health, reduced quality of life, and increased hospitalization rates leading to higher health expenditures.

Nowadays all existing measures for improving adherence to treatment and promoting healthy lifestyle can be divided into the following categories: behavioral, educational, affective, economic and combined. At the same time development of confidential doctor/patient relations is playing the crucial role as well as monitoring of adherence through modern technical devices.

Conclusions. For a long time many countries have been failing to effectively address the problem of insufficient adherence. However, in recent years we saw emergence of technical means to effectively monitor compliance with medical advice related to treatment and disease prevention making it possible to consider such means as most promising solution to this problem.

Scope of application. Improvement of public health because of improved compliance with medical advice related to treatment and disease prevention.

Keywords: adherence to treatment, compliance, public health, medical advice, medical awareness.

References

1. Avdeeva MV., Lobzin JuV., Luchkevich VS. Upravlenie faktorami riska hronicheskih neinfekcionnyh zabolevanij na osnove strahovogo risk-menedzhmenta [Control of chronic noncommunicable diseases based on insurance risk-management]. Sotsial'nye aspekty zdorov'ya naseleniya [serial online] 2014 [cited 2016 Mar 15]; 38 (4). Available from: http://vestnik.mednet.ru/content/view/584/lang?ru (In Russian).
2. Zelionko AV, Luchkevich VS, Avdeeva MV. Ispol'zovanie kompetentnostnogo podhoda k ocenke medicinskoj informirovannosti i priverzhennosti gorodskih zhitelej zdorovomu obrazu zhizni [Using a competence-based approach to the assessment of health awareness and adherence of urban population to healthy lifestyle]. Profilakticheskaja i klinicheskaja medicina 2014; 53 (4); 42-48 (In Russian).
3. Adherence to long-term therapies. Evidence for action. Geneva, Switzerland: World Health Organization WHO [Online]. 2003 [cited 2016 February 29]. Available from: http://whqlibdoc.who.int/publications/2003/9241545992.pdf
4. Ambegaonkar AJ, Ceridwyn N, D’Angio R, Feinberg JL, Gables L, Johnson S, et al. Adult meducation: improving medication adherence in older adults [Online]. 2006 [cited 2016 February 28]. Available from: http://www.adultmeducation.com/downloads/Adult_Meducation.pdf
5. Armitage ChJ, Conner M. Social cognition models and health behaviour: a structured review. Psychology & Health 2000; (15): 173-189.
6. Awad AG. Antipsychotic medications: compliance and attitudes towards treatment. Curr Opin Psychiatry 2004; (17): 75-80.
7. Bender B, Milgrom H, Apter A. Adherence intervention research: what have we learned and what do we do next? Journal Allergy Clin Immunol 2003; (112): 489-494.
8. Brown BG, Bardsley J, Poulin D, Hillger LA, Dowdy A. Moderate dose, three-drug therapy with niacin, lovastatin, and colestipol to reduce low-density lipoprotein cholesterol <100 mg/dl in patients with hyperlipidemia and coronary artery disease. Am J Cardiol 1997; 80 (2): 111-115.
9. Burke LE, Dunbar-Jacob JM, Hill MN. Compliance with cardiovascular disease prevention strategies: a review of the research. Ann Behav Med 1997; (19): 239-263.
10. Burke LE, Ockene IS. Compliance in healthcare and research. New York: Furtura Publishing; 2001.
11. Calderón-Larrañaga A, Diaz E, Poblador-Plou B, Gimeno-Feliu LA, Abad-Díez JM, Prados-Torres A. Non-adherence to antihypertensive medication: the role of mental and physical comorbidity. Int J Cardiol 2016; (207): 310-316.
12. Chedid F, Falk M. High degree of adherence to statin therapy among the elderly despite high frequency of side effects. Healthy aging & clinical care in the elderly 2011; (3): 1-7.
13. Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther 2001; (23): 1296-1310.
14. Cochrane MG, Bala MV, Downs KE, Mauskopf J, Ben Joseph RH. Inhaled corticosteroids for asthma therapy: patient compliance, devices, and inhalation technique. Chest 2000; (117): 542-550.
15. Cooper LA, Roter DL, Bone LR. A randomized controlled trial of interventions to enhance patient-physician partnership, patient adherence and high blood pressure control among ethnic minorities and poor persons. Implement Sci 2009; (19): 4-7.
16. Costas-Muniz R, Leng J, Aragones A, Ramirez J, Roberts N, Mujawar MI, et al. Association of socioeconomic and practical unmet needs with self-reported nonadherence to cancer treatment appointments in low-income Latino and Black cancer patients. Ethn Health 2016; 21 (2): 118-128.
17. Cramer JA, Rosenheck R. Compliance with medication regimens for mental and physical disorders. Psychiatr Serv 1998; (49): 96-201.
18. DiMatteo MR. Variations in patients' adherence to medical recommendations: a quantitative review of 50 years of research. Med Care 2004; (42): 200-209.
19. DiMatteo MR, Giordani PJ, Lepper H.S. Patient adherence and medical treatment outcomes: a meta-analysis. Med Care 2002; (40): 794-811.
20. Einarson TR. Drug-related hospital admissions. Ann Pharmacother 1993; (27): 832-840.
21. Fang R, Li X. Electronic messaging support service programs improve adherence to lipid-lowering therapy among outpatients with coronary artery disease: an exploratory randomized control study. J Clin Nurs 2016; 25 (5-6): 664-671.
22. Gibson PG, Coughlan J, Wilson AJ, Abramson M, Bauman A, Hensley MJ, et al. Self-management education and regular practitioner review for adults with asthma. The Cochrane database of systematic reviews 2000; (2): CD001117.
23. Gibson PG, Powell H, Coughlan J, Wilson AJ, Abramson M, Haywood P, et al. Self-management education and regular practitioner review for adults with asthma. The Cochrane database of systematic reviews 2003; (1): CD001117.
24. González-Buenoa J, Vega-Cocab MD, Rodríguez-Péreza A, Toscano-Guzmána MD, Pérez-Guerreroc C, Santos-Ramosd B. Intervenciones para la mejora de la adherencia al tratamiento en pacientes pluripatológicos: resumen de revisiones sistemáticas. Aten Primaria 2016; 48 (2): 121-130.
25. Haddad M, Inch C, Glazier RH, Wilkins AL, Bayoumi A, Rourke S. Patient support and education for promoting adherence to highly active antiretroviral therapy for HIV/AIDS. The Cochrane database of systematic reviews 2000; (3) 1-10.
26. Hameed MA, Tebbit L, Jacques N, Thomas M, Dasgupta I. Non-adherence to antihypertensive medication is very common among resistant hypertensives: results of a directly observed therapy clinic. Journal of Human Hypertension 2016; (30): 83-89.
27. Hamine S, Gerth-Guyette E, Faulx D, Green BB, Ginsburg AS. Impact of mHealth chronic disease management on treatment adherence and patient outcomes: a systematic review. J. Med Internet Res 2015; (17): å52.
28. Hampson SE, Skinner TC, Hart J, Storey L, Gage H, Foxcroft D, et al. Effects of educational and psychosocial interventions for adolescents with diabetes mellitus: a systematic review. Health Technol Assess 2001; (5): 1-79.
29. Haskard Zolnierek KB, DiMatteo. Physician communication and patient adherence to treatment: a meta-analysis. Med Care 2009; 47 (8): 826-834.
30. Haynes RB, Montague P, Oliver T, McKibbon KA, Brouwers MC, Kanani R. Interventions for helping patients to follow prescriptions for medications. The Cochrane database of systematic reviews 2000; (2): CD000011.
31. Haynes RB, Yao X, Degani A, Kripalani S, Garg A, McDonald H. Interventions to enhance medication adherence. The Cochrane database of systematic reviews 2006; (4): 1-96.
32. Henriksson F, Agardh CD, Berne C, Bolinder J, Lönnqvist F, Stenström P, et al. Direct medical costs for patients with type 2 diabetes in Sweden. Journal of Internal Medicine 2000; (248): 387-396.
33. Jung MJ, Jeong Y. Motivation and self-management behavior of the Individuals with chronic low back pain. Orthopaedic Nursing 2016; (25): doi: 10.1097/NOR.0000000000000233.
34. Jung O, Gechter JL, Wunder C, Paulke A, Bartel C, Geiger H. Resistant hypertension? Assessment of adherence by toxicological urine analysis. J Hypertens 2013; 31 (4): 766-774.
35. Kaptein A, Weinman J. Health Psychology. Malden: BPS Blackwell; 2004.
36. Kim S, Shin DW, Yun JM, Hwang Y, Park SK, Ko Y, et al. Medication adherence and the risk of cardiovascular mortality and hospitalization among patients with newly prescribed antihypertensive medications. Hypertension 2016; (67): 506-512.
37. Lorig K, Holmann H. Arthritis self-management studies: a twelve year review. Health Educ Q 1993; (20): 17-28.
38. McDonald HP, Garg AX, Haynes RB. Interventions to enhance patient adherence to medication prescriptions: scientific review. JAMA 2002; (288): 2868-2879.
39. Miller TA. Health literacy and adherence to medical treatment in chronic and acute illness: a meta-analysis. Patient Educ Couns 2016; doi: 10.1016/j.pec.2016.01.020.
40. Napolitano F, Napolitano P, Angelillo IF. Medication adherence among patients with chronic conditions in Italy. European journal of public health 2016; 26 (1): 48-52.
41. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med 2005; (353): 487-497.
42. Peterson AM, Takiya L, Finley R. Meta-analysis of interventions to improve drug adherence in patients with hyperlipidemia. Pharmacotherapy 2003; (23): 80-87.
43. Peterson AM, Takiya L, Finley R. Meta-analysis of trials of interventions to improve medication adherence. Am J Health Syst Pharm 2003; (60): 657-665.
44. Piette JD, Heisler M, Krein S. The role of patient-physician trust in moderating medication nonadherence due to cost pressures. Arch Intern Med 2005; (165): 1749-1755.
45. Ratanawongsa N, Karter AJ, Quan J, Parker MM, Handley M, Sarkar U, et al. Reach and validity of an objective medication adherence measure among safety net health plan members with diabetes: a cross-sectional study. J Manag Care Spec Pharm 2015; (8): 688-698.
46. Roter DL, Hall JA, Merisca R, Nordstrom B, Cretin D, Svarstad B. Effectiveness of interventions to improve patient compliance: a meta-analysis. Med Care 1998; (36): 1138-1161.
47. Simon-Tuval T, Neumannb PJ, Greenberga D. Cost-effectiveness of adherence-enhancing interventions: a systematic review. Expert Review of Pharmacoeconomics & Outcomes Research 2016; 16 (1): 67-84.
48. Sluijs EM, Knibbe JJ. Patient compliance with exercise: different theoretical approaches to short-term and long-term compliance. Patient Educ Couns 1991; (17): 191-204.
49. Sokol MC, McGuigan KA, Verbrugge RR. Impact of medication adherence on hospitalization risk and healthcare cost. Med Care 2005; (43): 521-530.
50. Takiya LN, Peterson AM, Finley RS. Meta-analysis of interventions for medication adherence to antihypertensives. Ann Pharmacother 2004; (38): 1617-1624.
51. Thakkar J, Kurup R, Laba TL, Santo K, Thiagalingam A, Rodgers A, et al. Mobile telephone text messaging for medication adherence in chronic disease: a meta-analysis. JAMA Intern Med 2016; doi: 10.1001/jamainternmed.2015.7667.
52. Timmerman L, Stronks DL, Groeneweg G, Huygen FJ. The value of medication-specific education on medication adherence and treatment outcome in patients with chronic pain: a randomized clinical trial. Pain Med [serial online] 2016 [cited 2016 February 29]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 26921890
53. Timmerman L, Stronks DL, Groeneweg JG, Huygen FJ. Prevalence and determinants of medication non-adherence in chronic pain patients: a systematic review. Acta Anaesthesiol Scand [serial online] 2016 [cited 2016 February 29]; Available from: http://www.ncbi.nlm.nih.gov/pubmed/26860919.
54. van Dulmen S, Sluijs E, van Dijk L. Furthering patient adherence: a position paper of the international expert forum on patient adherence based on an Internet forum discussion. BMC Health Serv Res 2008; (8): 8-47.
55. Wald DS, Butt S, Bestwick JP. One-way versus two-way text messaging on improving medication adherence: meta-analysis of randomized trials. The American journal of medicine 2015; 128 (10): 1139.e1-1139.e5.
56. Wroth TH, Pathman DE. Primary medication adherence in a rural population: the role of the patient-physician relationship and satisfaction with care. J Am Board Fam Med 2006; 19 (5): 478-486.
57. Yao X, Abraham N, Alexander C. Effect of adherence to oral anticoagulants on risk of stroke and major bleeding among patients with atrial fibrillation. J Am Heart Assoc 2016; DOI:10.1161/JAHA.115.003074

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