E.B. Tsybikova
Federal Research Institute for Health Organization and Informatics of Ministry of Health of the Russian Federation, Moscow

Summary. Background. In the first decade of the XXI ^st century, an overall spread of tuberculosis combined with HIV-infection (co-infection) was evidenced in Russia, and this has urged a new tide of growing morbidity and mortality as concerns both nosologies.

Aim of the study: to identify and evaluate certain epidemiologic indicators for scoring the scale of spread of the aforementioned co-infection at the level of Constituent Territories of the Russian Federation.

Materials and Methods: Functioning indicators for tuberculosis and for HIV-infection for 2000-2011 were implemented for this analysis. The grade of spread of co-infection was established for 83 Constituent Territories of Russia. The techniques of ranging these CT along the aforementioned indicators and co-indicators was implemented. Correlation analysis was used. Coefficients of Pearson were calculated. Coefficient of correlation was significant when exceeding 0.21 (n=81). A significance level of less than 0.05 (p) was used. Established variables were used for evaluation of the magnitude of an error.

Results: Significant spread of HIV-infection among TB patients was identified only in 43 Constituent Territories of the Russian Federation (53% of their total number), while wide-spread TB among HIV-infected patients was significant in all Constituent Territories without any exception. Quite a row of epidemiological factors common for both nosologies were identified in this study enabling the formation of a unified specific cohort of patients aged 25-34 being appropriate for regular co-infective prevention follow-up for detection of either TB- or HIV-infection , accordingly, depending on the primary case. Correlation analysis showed close relationship between primarily identified patients with meningitis tuberculosa and co-infective patients. The more was the proportion of HIV-infection in TB patients, the more was incidence of meningitis tuberculosa registered.

Conclusion: Significant spread of HIV-infection among TB patients was identified only in 43 Constituent Territories of the Russian Federation (53% of their total number), while wide-spread TB among HIV-infected patients was significant in all Constituent Territories without any exception. There was performed the formation of a unified specific cohort of male patients only aged 25-34 being appropriate for regular co-infective prevention first-line follow-up for detection of either TB- or HIV-infection , accordingly, depending on the primary case. It was meningitis tuberculosa that was used as a marker of co-infection.

Keywords. Epidemiologic nosology indicators; tuberculosis combined with HIV-infection; disease revelation/identification; disease wide-spread; meningitis; correlation analysis.

References

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