DOI: 10.21045/2071-5021-2017-53-1-11

Punga VV.¹, Tsybikova E.B.², Yakimova M.A.¹, Izmaylova T.V.^1
1Central Research TB Institute, Moscow
²Federal Research Institute for Health Organization and Informatics of Ministry of Health of the Russian Federation, Moscow

Contacts: Erzheny Tsybikova, e-mail: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it
Information about authors:
Punga V.V., http://orcid.org/0000-0003-0564-2099
Tsybikova E.B., http://orcid.org/0000-0002-9131-3584
Yakimova M.A., http://orcid.org/0000-0002-3892-6402
Izmailova T.V., http://orcid.org/0000-0002-4197-355Õ

Acknowledgments.The study had no sponsorship.

Conflct of interests. The authors declare no conflict of interest.

Abstract. Significance. Currently Russia reports a high prevalence of TB-HIV co-infection. The number of new TB-HIV cases reached 16100 in 2015 or 19% of the total number of new TB cases. Clinical progression of TB in HIV patients is characterized by rapid progress and trend towards wide dissemination. Multidrug extensive drug resistant Mycobacterium tuberculosis highly increases risk of mortality among such patients. Cohort analysis makes it possible to objectively estimate treatment results for TB-HIV patients and identify regions of the Russian Federation with effective TB control.

The study purpose: to estimate treatment results for TB-HIV patients using cohort analysis data.

Materials and methods. TB and HIV indicators for 2012-2015 calculated using reporting statistical forms #8 and #61 as well as data from reporting forms according to the Ministry of Health Order #50 on treatment results for 1354 TB-HIV patients in 2014 received from 13 Russian regions.

Results: Cohort analysis of treatment results for newly diagnosed patients with TB and HIV co-infection conducted in 13 Russian regions showed that structure of treatment outcomes narrowed to only three outcomes: effective - 47.2% of cases; deaths - 26.2% or over a quarter of the total number of patients registered for treatment; and ineffective - 16.1%. Other treatment outcomes (early treatment termination, dropouts) hardly developed due to high mortality during the first months in treatment.

Keywords: Lung TB; HIV; TB-HIV co-infection; cohort analysis; mortality.

References

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