DOI: 10.21045/2071-5021-2017-53-1-11
Punga VV.1, Tsybikova E.B.2, Yakimova M.A.1, Izmaylova T.V.1
1Central Research TB Institute, Moscow
2Federal Research Institute for Health Organization and Informatics of Ministry of Health of the Russian Federation, Moscow
Contacts: Erzheny Tsybikova, e-mail:
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Information about authors:
Punga V.V., http://orcid.org/0000-0003-0564-2099
Tsybikova E.B., http://orcid.org/0000-0002-9131-3584
Yakimova M.A., http://orcid.org/0000-0002-3892-6402
Izmailova T.V., http://orcid.org/0000-0002-4197-355Õ
Acknowledgments.The study had no sponsorship.
Conflct of interests. The authors declare no conflict of interest.
Abstract. Significance. Currently Russia reports a high
prevalence of TB-HIV co-infection. The number of new TB-HIV cases
reached 16100 in 2015 or 19% of the total number of new TB cases.
Clinical progression of TB in HIV patients is characterized by rapid
progress and trend towards wide dissemination. Multidrug extensive drug
resistant Mycobacterium tuberculosis highly increases risk of mortality
among such patients. Cohort analysis makes it possible to objectively
estimate treatment results for TB-HIV patients and identify regions of
the Russian Federation with effective TB control.
The study purpose: to estimate treatment results for TB-HIV patients using cohort analysis data.
Materials and methods. TB and HIV indicators for
2012-2015 calculated using reporting statistical forms #8 and #61 as
well as data from reporting forms according to the Ministry of Health
Order #50 on treatment results for 1354 TB-HIV patients in 2014 received
from 13 Russian regions.
Results: Cohort analysis of treatment results for newly
diagnosed patients with TB and HIV co-infection conducted in 13 Russian
regions showed that structure of treatment outcomes narrowed to only
three outcomes: effective - 47.2% of cases; deaths - 26.2% or over a
quarter of the total number of patients registered for treatment; and
ineffective - 16.1%. Other treatment outcomes (early treatment
termination, dropouts) hardly developed due to high mortality during the
first months in treatment.
Keywords: Lung TB; HIV; TB-HIV co-infection; cohort analysis; mortality.
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