About this Journal Publication ethics Editorial Board Editorial Council Editorial Office For the Authors Contacts

News feeds

Journal in Databases

eLIBRARY.RU - ═└ËÎ═└▀ Ţ╦┼╩Ďđ╬══└▀ ┴╚┴╦╚╬Ď┼╩└

Google Scholar

Google Scholar

Main arrow Archive of previous Issues arrow ╣1 2017 (53) arrow TREATMENT RESULTS FOR PATIENTS WITH TB-HIV CO-INFECTION
Monday, 06 March 2017

DOI: 10.21045/2071-5021-2017-53-1-11

Punga VV.1, Tsybikova E.B.2, Yakimova M.A.1, Izmaylova T.V.1
1Central Research TB Institute, Moscow
2Federal Research Institute for Health Organization and Informatics of Ministry of Health of the Russian Federation, Moscow

Contacts: Erzheny Tsybikova, e-mail: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it
Information about authors:
Punga V.V.,
Tsybikova E.B., http://orcid.org/0000-0002-9131-3584
Yakimova M.A., http://orcid.org/0000-0002-3892-6402
Izmailova T.V., http://orcid.org/0000-0002-4197-355Ň

Acknowledgments.The study had no sponsorship.

Conflct of interests. The authors declare no conflict of interest.

Abstract. Significance. Currently Russia reports a high prevalence of TB-HIV co-infection. The number of new TB-HIV cases reached 16100 in 2015 or 19% of the total number of new TB cases. Clinical progression of TB in HIV patients is characterized by rapid progress and trend towards wide dissemination. Multidrug extensive drug resistant Mycobacterium tuberculosis highly increases risk of mortality among such patients. Cohort analysis makes it possible to objectively estimate treatment results for TB-HIV patients and identify regions of the Russian Federation with effective TB control.

The study purpose: to estimate treatment results for TB-HIV patients using cohort analysis data.

Materials and methods. TB and HIV indicators for 2012-2015 calculated using reporting statistical forms #8 and #61 as well as data from reporting forms according to the Ministry of Health Order #50 on treatment results for 1354 TB-HIV patients in 2014 received from 13 Russian regions.

Results: Cohort analysis of treatment results for newly diagnosed patients with TB and HIV co-infection conducted in 13 Russian regions showed that structure of treatment outcomes narrowed to only three outcomes: effective - 47.2% of cases; deaths - 26.2% or over a quarter of the total number of patients registered for treatment; and ineffective - 16.1%. Other treatment outcomes (early treatment termination, dropouts) hardly developed due to high mortality during the first months in treatment.

Keywords: Lung TB; HIV; TB-HIV co-infection; cohort analysis; mortality.


  1. Lechenie tuberkuleza: rekomendatsii. 4-e izd. [Tuberculosis treatment: Manual. 4-nd ed.]. Geneva. WHO Regional Office for Europe. 2011. 183 p. (In Russian).
  2. Rukovodyashchie printsipy dlya intensivnogo vyyavleniya tuberkuleza i profilakticheskoy terapii izoniazidom u lyudey, zhivushchikh s VICh, v usloviyakh nekhvatki resursov [Guidelines on intensive tuberculosis detection and izoniazid preventive therapy for people living with HIV in resource-limited settings]. Geneva. WHO Regional Office for Europe; 2011. 39 p. [Online] [cited 2016 Oct 25]. Available from: http://apps.who.int/iris/bitstream/10665/44472/3/9789244500705_rus.pdf. (In Russian).
  3. Tuberkulez: vyyavlenie, lechenie i monitoring po K. Tomenu. Voprosy i otvety [Tuberculosis: detection, treatment and monitoring using K. Tomen method. Questions and answers]. [Transl. from Eng.]. Moscow: Ves' mir. 2004. 387 p. (In Russian).
  4. Tuberkulez v XXI veke: Problemy i puti resheniya [Tuberculosis in XXI century: Challengers and solution]. Trudy FGBNU źTsentral'nyy nauchno-issledovatel'skiy institut tuberkuleza╗ Moscow: OOO źGalleya-Print╗; 2015. 5-19. (In Russian).
  5. Federal'nye klinicheskie rekomendatsii po diagnostike i lecheniyu tuberkuleza u bol'nykh s VICh-infektsiey [Federal clinical recommendations on tuberculosis diagnosis and treatment in HIV-infected patients]. Moscow: Izdatel'stvo źTriada╗; 2014. 54 p. (In Russian).
  6. Tsybikova E.B., Sabgayda T.P. Epidemiologiya tuberkuleza, sochetannogo s VICh-infektsiey [Epidemiology of tuberculosis co-infected with HIV]. Zdravookhranenie Rossiyskoy Federatsii 2012; (6): 7-11. (In Russian).
  7. Gandhi NR, Moll A, Sturm AW, Pawinski R, Govender T, Laloo U, et al. Extensively drug resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet 2006; 368 (9547): 1575-1580.
  8. Guidelines for the programmatic management of drug-resistant tuberculosis: emergency update 2008. Geneva: World Health Organization; [Online] 2008 [cited 2017 Jun 25]. Available from: http://apps.who.int/iris/bitstream/10665/43965/1/9789241547581_eng.pdf
  9. WHO Three Iĺs Meeting: Intensified case finding (ICF), Izoniazid preventive therapy (IPT) and TB Infection control (IC) for people living with HIV. [Online] [cited 2017 Jun 25]. Available from: http://www.who.int/hiv/pub/meetingreports/WHO_3Is_meeting_report.pdf?ua=1

Views: 7670

Be first to comment this article

Write Comment
  • Please keep the topic of messages relevant to the subject of the article.
  • Personal verbal attacks will be deleted.
  • Please don't use comments to plug your web site. Such material will be removed.
  • Just ensure to *Refresh* your browser for a new security code to be displayed prior to clicking on the 'Send' button.
  • Keep in mind that the above process only applies if you simply entered the wrong security code.

Code:* Code

Last Updated ( Monday, 03 April 2017 )
< Prev   Next >
home contact search contact search