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Main arrow Archive of previous Issues arrow ╣1 2011 (17) arrow Efficiency of vaccine of Calmette and Guerin immunization in children born by HIV-infected mothers
Efficiency of vaccine of Calmette and Guerin immunization in children born by HIV-infected mothers Print
Tuesday, 01 March 2011

Nechaeva O.B.1, Skachkova E.I.2, Podymova A.S.3, Popkova G.G.3, Eysmont N.V.3
1
- Federal Public Health Institute, Moscow
2 - Ministry of Health and Social Development , Moscow
3 - Sverdlovsk regional antitubercular dispensary , Ekaterinburg

Sverdlovsk region takes the first place in Russia in the number of children who were born by HIV-infected mothers. More than 40 % of HIV-infected women gave birth to children. HIV- infected mothers gave birth to children mainly at ages till 25 years (74.8 %), never were married (65.6 %); women as a rule were not registered in womenĺs health clinic (38.3 %) and did not receive antiretroviral therapy (81.4 %) during pregnancy.

In the region, 68.9 % of children born by HIV-infected mothers have got anti-TB vaccination , mainly with modified vaccine of Calmette and Guerin (92.7 %), often in a maternity hospital (44.2 %). Among children who have got anti- TB vaccination at early ages, "curve " in the tuberculine tests was less often (0.7 % against 4.4 %, P <0.01) and tuberculosis morbidity was registered rarely (0.8 % against 5.5 %, P <0.001), general case mortality was lower (1.0 % against 4.8 %, P <0.01).

In children born by HIV-infected mothers and vaccinated with vaccine of Calmette and Guerin, HIV-infection was registered significantly more rarely than in children who were not anti-TB vaccinated (19.2 % against 44.3 %, P <0.001). In spite of the fact that vaccinated with vaccine of Calmette and Guerin HIV-infected children born by HIV-infected mothers have rarely got antiretroviral therapy during child births, they have HIV-infection developed later than in children who have not got TB vaccination, that is, in the ages of till 1 year ľin 25.2 % and 45.0 % of all cases (P <0.002) respectively, in the ages of 2 years and more in 53.9 % and 22.5 % of all cases (P <0.001) respectively. vaccine of Calmette and Guerin not only promotes reduction in TB contamination and morbidity , but also increases terms of HIV-infection development , and in some cases prevents contamination in children born by HIV-infected mothers.

Key words: tuberculosis, HIV-infection , vaccine of Calmette and Guerin, children born by HIV-infected mothers.

References

  1. Belilovskiy EM, Borisov SE, Skachkova EI, Son IM, Galkin VB, Danilova ID, Pashkevich DD. Zabolevaemost tuberkulezom v Rossiyskoy Federatsii [Tuberculosis morbidity in Russian Federation]. V kn: Tuberkulez v Rossiyskoy Federatsii v 2009 g. Analiticheskiy obzor statisticheskikh pokazateley po tuberkulezu, ispolzuemykh v Rossiyskoy Federatsii [In: Tuberculosis in Russian Federation in 2009. Analysis and review of statistical measures of tuberculosis used in Russian Federation]. Moscow; 2010. p. 22-60.
  2. Nechaeva OB, Kozhekina NV. Tuberkulez u zhenshchin detorodnogo vozrasta v Sverdlovskoy oblasti [Tuberculosis in fertility age females in Sverdlovsk Region]. Rossiyskiy meditsinskiy zhurnal 2009;(1):6-9.
  3. Skachkova EI, Shestakov MG, Temirdzhanova SYu. Dinamika i sotsialno-demograficheskaya struktura tuberkuleza v Rossiyskoy Federatsii, yego zavisimost ot urovnya zhizni [Dynamics and structure of tuberculosis in Russian Federation. Dependence from living standards]. Tuberkulez i bolezni legkikh 2009;(7):4-8.
  4. Kakorina EP, Mikhaylova LA, Mikhaylova YuV, Son IM, Skachkova EI, Borisov SE, Bogorodskaya EM, Shilova MV, Punga VV, Kononets AS, Sidorova SV, Belilovskiy EM, Danilova ID, Yakubovyak V, Korobitsyn A. V. van Gemert. Tuberkulez v Rossiyskoy Federatsii 2006 g. Analiticheskiy obzor osnovnykh statisticheskikh pokazateley po tuberkulezu, ispolzuemykh v Rossiyskoy Federatsii [Tuberculosis in Russian Federation in 2006. Analysis and review of statistical measures of tuberculosis used in Russian Federation]. Moscow: OOO źIzdatelstvo źTriada╗, 2007. 126 p.
  5. Frolova OP, Belilovskiy EM, Shinkareva IG, Yurasova E.D. VICh-infektsiya v Rossiyskoy Federatsii i ee vliyanie na zabolevaemost tuberkulezom [HIV-infection in Russian Federation and its influence on tuberculosis morbidity]. V kn.: Tuberkulez v Rossiyskoy Federatsii v 2009 g. Analiticheskiy obzor statisticheskikh pokazateley po tuberkulezu, ispolzuemykh v Rossiyskoy Federatsii [In: Tuberculosis in Russian Federation in 2009. Analysis and review of statistical measures of tuberculosis used in Russian Federation]. Moscow; 2010. p. 128-139.
  6. Shilova MV. Epidemicheskaya obstanovka po tuberkulezu v Rossiyskoy Federatsii k nachalu 2009 g [Epidemic situation with tuberculosis in Russian Federation at the start of 2009]. Tuberkulez i bolezni legkikh 2010;(5):14-21.
  7. Folks TM and Clyde E.Hart. The Life Cycle of Human Immunodeficiency Virus Type I. AIDS (Etiology, Diagnosis, Treatment and Prevention) Philadelphia-New York. 1997. Vol.746. P. 29-45.

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