Nechayeva O.B., Eismont N.V., Spiridonova L.G.
¹Federal Research Institute for Health Organization and Informatics of Ministry of Health and Social Development of the Russian Federation, Moscow
²The Orenburg State Medical Academy

Summary. The Region of Sverdlovsk is unique among constituent territories in the RF for its concentration of the number of patients with TB, with HIV-infection, and with combined infection of both of them. It is also prominent for its unfavorable epidemiologic situation for either of the both infections.

In 2004-2008 in the Region of Sverdlovsk, TB morbidity was higher in overall pool of HIV-infected patients (irrespective of early or advanced stages of HIV-disease), as well as in adult solely HIV-infected patients (irrespective of gender), than in the HIV-free general population. Situation with mortality developed just upon the same lines.

HIV-infected patients of this Region presented more rarely a pulmonary destructive tuberculosis, than HIV-free general population, but more frequently – bacillary tuberculosis of the respiratory organs; they also produced in the latter cases a more frequently multiple drug resistance of TB mycobacteria for anti-TB preparations.

Primary identified TB patients with advanced HIV-process more typically presented haematogenicaly disseminated tuberculosis, inclusive of generalized specific process.

The spread of HIV-infection strongly affected the wide-spread of tuberculosis in the Region of Sverdlovsk in 2004-2008.

There exists innumerable domestic and international literature on combination of TB- and HIV-infection, nevertheless, no comparative study of main indicators of tuberculosis among HIV-patients (including early, as well as advanced stages) compared to those of general HIV-free population has yet appeared before our trial of this. Still more, there has been no reports on calculated probability for a HIV-patient to contract tuberculosis/to die from tuberculosis in comparison to an HIV-free patient.

Key words. pulmonary tuberculosis, Destructive tuberculosis, Bacillary tuberculosis, Haematogenicaly disseminated tuberculosis, HIV-infected patients, Early stage, Advanced stage, Combination of TB- and HIV-infection, HIV-free general population, Probabilities of death from TB

References

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