About this Journal Publication ethics Editorial Board Editorial Council Editorial Office For the Authors Contacts

News feeds

Journal in Databases


Google Scholar

Google Scholar

Wednesday, 15 April 2015

Tsybulskaya I.S.
Federal Research Institute for Health Organization and Informatics of Ministry of Health of the Russian Federation, Moscow

Abstract. The purpose of the study was to determine formation peculiarities of the childrens phenotype against the background of negative impact of external environmental factors during antenatal period and mechanism of their impact on the fetus and children.

Methods and data. The following environmental factors were analyzed: quality of mothers life (negative social and psychological impacts on pregnant woman) and ecological environment (residence in territories affected by Chernobyl accident). The following clinical manifestations were studied: metabolism, neurohormonal regulatory systems and vital systems participating in adaptative and compensatory reactions of the body, genetic status of somatic blood cells (DNA-repair response, protein polymorphism, mutagenesis).

More than two thousand children underwent a comprehensive examination, including evaluation of life quality of mothers for 672 children and 1382 children residing in radiation polluted areas (including 498 genetic testing).

Results. The author detected a stereotypic abient response of the fetus in early ontogenesis to the negative environmental exposure in the form of activated pituitary-thyroid system, metabolism (oxidation processes) and harmful influence in the form of reduced heterozygosis, DNA-repair response, mutagenesis and defects of neuro-vegetative-visceral sphere.

The harmful affect was mainly manifested in the fetus and in children following stress (including delivery) and during critical periods of childs growth and development (age 1-2 months, 9-10 months and in adolescents)

Conclusions. The author presents a principal scheme of the specific phenotype formation against the background of perinatal pathological impacts, and makes a hypothesis of constant deterioration when exposed to negative environmental factors of individual biological peculiarities in consecutive generations as well as the leading role that formation of a specific phenotype plays in the growing incidence of multifactorial diseases nowadays.

Keywords: environmental exposure; regulatory systems; energy supply; genetic apparatus of somatic cells; specific phenotype; evolutionary development programs (fetal programming); multifactorial diseases.


  1. Altukhov Yu.P., editor. Dinamika populyatsionnykh genofondov pri antropogennykh vozdeystviyakh [The dynamics of population genetic resources under anthropogenic influence]. Moscow: Nauka; 2004. 620 p. (In Russian)
  2. Baranov A.A., Tsybul'skaya I.S., Al'bitskiy V.Yu., Volkov I.M., Sharapova E.I. Zdorov'e detey Rossii. Sostoyanie i problemy [Russian childrens health. The state and problems]. Moscow. 1999. 273 p. (In Russian)
  3. Baranov V.S., Baranova E.V., Ivashchenko T.E., Aseev M.V. Genom cheloveka i geny predraspolozhennosti: vvedenie v prediktivnuyu meditsinu [Human genome and predisposition genes: introduction to prediction medicine]. St. Petersburg: Intermedika; 2000. 272 p. (In Russian)
  4. Krybus A.I. Vliyanie perinatal'noy gipoksii na formirovanie nevroticheskikh rasstroystv rastushchego organizma [Influence of perinatal hypoxia on formation of neurotic disorders in a growing organism]. Cand. Med. Sci. [thesis]. Moscow. 1988. 26 p. (In Russian)
  5. Lektsii po genetike. Genetika ontogeneza [Lecture on genetics. The genetics of ontogenesis] [Online] [cited 2015 Feb 01]. Available from: http://afonin-59-bio.narod.ru/2_heredity/2_heredity_lec/2_heredity_lec.htm (In Russian)
  6. Polonikov A.V., Ivanov V.P., Solodilova M.A. Ekologo-toksikogeneticheskaya kontseptsiya mul'tifaktorial'nykh zabolevaniy: ot ponimaniya etiologii do klinicheskogo primeneniya [Ecological and toxicogenetic concept of multifactor diseases: from understanding the etiology to clinical implementation] . Meditsinskaya genetika 2008; (11): 3-20. (In Russian)
  7. Sokur T.N. Reproduktivnoe zdorov'e zhenshchiny i kachestvo zdorov'ya potomstva v usloviyakh postoyannogo deystviya malykh doz radiatsii [Womens reproductive health and quality of posterity health in conditions of continuous low dose radiation]. Dr. Med. Sci.[thesis]. Moscow. 2001. 47 p. (In Russian)
  8. Monakhov M.V. Kachestvo zhizni semey s det'mi i ego vliyanie na zabolevaemost' i invalidizatsiyu detey [Life quality of families with children and its influence on morbidity and disability of children]. Cand. Med. Sci [thesis]. Moscow. 2009. 24 p. (In Russian)
  9. Spitsyn V.A. Ekologicheskaya genetika cheloveka [Human ecological genetics]. Moscow: Nauka; 2008. 503 p. (In Russian)
  10. Suskov I.I., Kuz'mina N.S., Baleva L.S., Sipyagina A.E. Problema indutsirovannoy genomnoy nestabil'nosti kak osnovy povyshennoy zabolevaemosti u detey, podvergayushchikhsya nizkointensivnomu vozdeystviyu radiatsii v malykh dozakh [The problem of induced genome instability as a basis for high level of morbidity in children exposed to low intensity and small dose radiation]. Radiobiologiya. Radioekologiya 2006; 46 (2): 167177. (In Russian)
  11. Tsybul'skaya I.S. Kliniko-fiziologicheskime osnovy adaptatsii novorozhdennykh detey [Clinical and physiological basis for adaptation of newborns]. Dr. Med. Sci. [thesis]. 1984. 49 p. (In Russian)
  12. Tsybul'skaya I.S., Tkachenko N.M., Bol'shakova T.D. Vliyanie gestozov na sostoyanie i razvitie ploda i rebenka [Influence of gestosis on the state and development of a fetus and a child]. Voprosy okhrany materinstva i detstva 1990; 3 (8): 66-71. (In Russian)
  13. Barker D.J. The fetal and infant origins of adult diseases. BMJ. 1990; 303: 1019.
  14. Barker D.J. Mothers Babies and health in later life. Ediurgh: Harcourt Brace & Co Ltd. 1998. 375 p.
  15. Barker DJ, Bagby SP. Developmental antecedents of cardiovascular disease: a historical perspective. 2005. 16 (9): 2537-2544.
  16. Cheung Y.B., Low L., Osmond C. et al. Fetal growth and early postnatal growth are related to blood pressure in adults. Hypertention. 2000; 36: 795805.
  17. Godfrey K.M., Barker D.J. Fetal programming and adult health. Public Health Nutr. 2001. 4 (2B): 611624.
  18. Hales C.N., Ozanne S.B. The dangerous road of catch-up growth. J. physiology. 2003. 547 (1): 5-10.
  19. Kim S.H., Mauron J., Gleason R. et al. Selection of carbohydrate to protein ratio and correlation with weight gain and body fat in rats allowed three dietary choices. J. VIT. Nutr. Res. 1991; 61: 166179.
  20. Lucas A. Programmingbt early nutrition: an experimental approach. J. Nutr. 1998; 128 (2): 4015-4065.

Views: 13935

Comments (1)
1. 08-10-2015 08:48
, , .
Written by ( This e-mail address is being protected from spam bots, you need JavaScript enabled to view it ) (Guest)

Write Comment
  • Please keep the topic of messages relevant to the subject of the article.
  • Personal verbal attacks will be deleted.
  • Please don't use comments to plug your web site. Such material will be removed.
  • Just ensure to *Refresh* your browser for a new security code to be displayed prior to clicking on the 'Send' button.
  • Keep in mind that the above process only applies if you simply entered the wrong security code.

Code:* Code

Last Updated ( Thursday, 16 April 2015 )
< Prev   Next >
home contact search contact search